Antidiabetic Activity of Polyherbal Extract on Alloxan Induced Diabetic Rats

Polyherbal extract which consists of ethanolic extract of MadhucaLatifolia, AristolochiaBracteata, AristolochiaIndica was investigated for its possible antidiabetic effect in alloxan-induced diabetic rats and to assess the synergistic activity of three plants. The animals were grouped into four six animals each. The first group received normal saline solution(0.9% sodium chloride), which was used as a negative control. The second group was used as a positive control. The third group received 200mg/kg bodyweight of polyherbal extract orally. The fourth group received 10mg/kg bodyweight of standard drug Glibenclamide orally. Diabetic rats treated with polyherbal extract at a dose of 200 mg/kg showed significant decrease in blood glucose level at 12th and 24thhour from initial levels. A significant time dependent antidiabetic effect was shown throughout the period of study. The antidiabetic effect of polyherbal extract was nearly comparable than that observed with glibenclamide.